کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8263040 | 1534869 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aging and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver
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کلمات کلیدی
HSCRetinoid X receptorsPBSDM1αSMARXRVDRterminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelingGFAPIBA1STZPPARDAPI1α-hydroxylase - 1α-هیدروکسیلاز4′,6-diamidino-2-phenylindole - 4 '، 6-دیامیدینو-2-فنیلینولMPO - DFOstreptozotocin - استرپتوزوتوسینstandard deviation - انحراف معیارTUNEL - تونلDiabetes mellitus - دیابت قندیDiabetes mellitus type 1 - دیابت نوع 1Aging - سالخوردگیHepatic stellate cell - سلول ستاره ای کبدیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)phosphate buffer saline - فسفات بافر شورLipid droplets - قطرات لیپیدionized calcium-binding adapter molecule 1 - ملکول آداپتور اتصال دهنده کلسیم یونیزه 1myeloperoxidase - میلوپراکسیداز Glial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالLiver - کبدperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیومVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Diabetes mellitus (DM) is a metabolic disorder associated with serious liver complications. As a metabolic chronic disease, DM is very common in the elderly. Recent studies suggest ameliorating effects of vitamin D on metabolic and oxidative stress in the liver tissue in an experimental model of DM. The aim of this study was to investigate the expression of vitamin D receptors (VDRs) and 1α-hydroxylase, the key enzyme for the production of active vitamin D form (calcitriol) in the liver during long-term diabetes mellitus type 1 (DM1) in aging rats. We performed immunohistochemical analysis of liver expression of 1α-hydroxylase and VDRs during aging in long-term streptozotocin-induced DM1. 1α-Hydroxylase was identified in the monocyte/macrophage system of the liver. In addition to the nuclear expression, we also observed the expression of VDR in membranes of lipid droplets within hepatocytes. Aging and long-term DM1 resulted in significant increases in the number of 1α-hydroxylase immunoreactive cells, as well as the percentage of strongly positive VDR hepatocytes. In conclusion, the liver has the capacity for active vitamin D synthesis in its monocyte/macrophage system that is substantially increased in aging and long-term diabetes mellitus. These conditions are also characterized by significant increases in vitamin D receptor expression in hepatocytes. The present study suggests that VDR signaling system could be a potential target in prevention of liver complications caused by diabetes and aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 72, December 2015, Pages 167-176
Journal: Experimental Gerontology - Volume 72, December 2015, Pages 167-176
نویسندگان
Ana Vuica, Lejla FerhatoviÄ HamziÄ, Katarina VukojeviÄ, Milka JeriÄ, Livia Puljak, Ivica GrkoviÄ, Natalija FilipoviÄ,