کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8264644 | 1534891 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent
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کلمات کلیدی
4-HNE4-hydroxynonenalS6KTORcranSOD2SOD1MAPK - MAPKRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهS6 kinase - S6 کینازNutraceutical - بیضه ایOxidative stress - تنش اکسیداتیوinverted repeat - تکرار معکوسAging - سالخوردگیsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1Superoxide dismutase 2 - سوکسوکس دیسموتاز 2Dietary intervention - مداخلات تغذیه ایLife stage - مرحله زندگیtarget of rapamycin - هدف از رپامایسینCranberry - کران بریMAP kinase - کیناز MAPbotanical - گیاه شناسی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Many nutraceuticals and pharmaceuticals have been shown to promote healthspan and lifespan. However, the mechanisms underlying the beneficial effects of prolongevity interventions and the time points at which interventions should be implemented to achieve beneficial effects are not well characterized. We have previously shown that a cranberry-containing nutraceutical can promote lifespan in worms and flies and delay age-related functional decline of pancreatic cells in rats. Here we investigated the mechanism underlying lifespan extension induced by cranberry and the effects of short-term or life stage-specific interventions with cranberry on lifespan in Drosophila. We found that lifespan extension induced by cranberry was associated with reduced phosphorylation of ERK, a component of oxidative stress response MAPK signaling, and slightly increased phosphorylation of AKT, a component of insulin-like signaling. Lifespan extension was also associated with a reduced level of 4-hydroxynonenal protein adducts, a biomarker of lipid oxidation. Moreover, lifespan extension induced by cranberry was partially suppressed by knockdown of SOD2, a major mitochondrial superoxide scavenger. Furthermore, cranberry supplementation was administered in three life stages of adult flies, health span (3-30Â days), transition span (31-60Â days) and senescence span (61Â days to the end when all flies died). Cranberry supplementation during any of these life stages extended the remaining lifespan relative to the non-supplemented and life stage-matched controls. These findings suggest that cranberry supplementation is sufficient to promote longevity when implemented during any life stage, likely through reducing oxidative damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 50, February 2014, Pages 57-63
Journal: Experimental Gerontology - Volume 50, February 2014, Pages 57-63
نویسندگان
Yaning Sun, Jason Yolitz, Thomas Alberico, Xiaoping Sun, Sige Zou,