Keywords: Agmatine; Antidepressants; Central nervous system; Depression; Neuroprotection; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARE; antioxidant response element; BDNF; brain-derived-neurotrophic factor; BBB; blood-brain barrier; CRE; cAMP
مقالات ISI (ترجمه نشده)
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Keywords: AbA; Aureobasidin A; ABC; ATP-binding cassette; AMPK; AMP-activated protein kinase; ATG; Autophagy-related; ATP; Adenosine triphosphate; C1P; Ceramide-1-phosphate; CERS; Ceramide synthase; CK2; Casein kinase II; CLS; Chronological lifespan; CMA; Chaperone
Keywords: 4E-BP; eukaryotic initiation factor 4E-binding protein;; ATscKO; Tsc1Lox/Lox adiponectin-cre+/â mice; ATscWT; Tsc1Lox/Lox adiponectin-creâ/â mice; C/EBP; CCAAT/enhancer-binding protein; CYC1; cytochrome c-1; DEPTOR; DEP domain-containing mTOR-intera
Keywords: ACAT; acyl-CoA cholesterol acyltransferase; ACC; acetyl CoA carboxylases; ACLY; ATP citrate lyases; ACSL; acyl CoA synthetases long chain family; ADRP; adipose differentiation related protein; AGP; advanced glycation end products; AGPAT; acylglycerophosph
Keywords: BDNF; brain derived neurotrophic factor; CAMKII; calmodulin-dependent protein kinase II; Ca2+; calcium; cAMP; cyclic adenosine monophosphate; CBS; cystathionine-β-synthase; CCI; chronic constriction injury; CFA; complete Freund's adjuvant; cGMP; cyclic
Transcriptome profiling reveals candidate cleft palate-related genes in cultured Chinese sturgeons (Acipenser sinensis)
Keywords: CL; craniofacial defect affecting the lip only; CLP; craniofacial defect affecting the lip and palate; CP; craniofacial defect affecting the palate only; IRF6; Interferon regulatory factor 6; MAFB; MAF bZIP transcription factor B; ARHGAP29; Rho GTPase act
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
Keywords: 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2- Deoxyglucose; 3-MA; 3-Methyladenine; ACC; Acetyl-CoA Carboxylase; Ad; adenoviruses; AKT; Protein Kinase B, also known as AKT; AMPK; Adenosine 5â²-monophosphate (AMP)-activated protein kinase; AT
Insulin-like peptides and DNA/tRNA methyltransferases are involved in the nutritional regulation of female reproduction in Nilaparvata lugens (Stål)
Keywords: bp; base pair; cDNA; DNA complementary to RNA; dNTP; deoxyribonucleoside triphosphate; kb; kilobase; kDa; kilodalton; ORF; open reading frame; UTR; untranslated region; RACE; rapid amplification of cDNA ends; qPCR; quantitative real time PCR; AAs; amino a
Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures
Keywords: HTT; Huntingtin; HD; Huntington's Disease; MID1; Midline 1; PP2A; Protein Phosphatase 2A; mHTT; Mutant Huntingtin; wtHTT; Wild type Huntingtin; S6K; 40S ribosomal S6 kinase; mTOR; Mammalian target of rapamycin; CGN; Cerebellar granule neurons; MAP2; Mic
SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas
Keywords: 4E-BP; 4E binding protein; AKT; v-akt murine thymoma viral oncogene homolog; BCC; basal cell carcinoma; BCNS; basal cell nevus syndrome; CCND1; cyclin D1; GLI; glioma-associated oncogene homolog; HEK; human embryonic kidney; ITRA; itraconazole; mTOR; mamm
Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum
Keywords: GSH; Cysteine transport; NGF; mTOR; Redox; Cerebellum; 4F2hc; 4F2 cell surface antigen; BBB; blood-brain barrier; BSO; L-buthionine-S-R-sulfoximine; CNS; central nervous system; DAPI; 4â²,6-diamidino-2-phenylindole DTPA; diethylenetriamine penta-acetic a
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Ecdysteroidogenesis and development in Heliothis virescens (Lepidoptera: Noctuidae): Focus on PTTH-stimulated pathways
Keywords: PG; prothoracic gland; BE; brain equivalent; PTTH; prothoracicotropic hormone; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; Akt; protein kinase B; TOR; target of rapamycin; EIA; enzyme immunoassay; 4E-BP; translational represso
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
AGC kinases, mechanisms of regulation âand innovative drug development
Keywords: AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy
Keywords: Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-Ã-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes
Keywords: Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p
Autophagy as a pharmacological target in hematopoiesis and hematological disorders
Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5â²-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;
Oncogenic mutations of PIK3CA and HRAS in carcinoma of cervix in South Indian women
Keywords: Oncogenic mutations; Cervical cancer; Peripheral blood; PCR-CTPP method; PIK3CA; Phosphatidylinositol-4,5-Bisphosphate; 3-Kinase Catalytic Subunit Alpha; HRAS; Harvey rat sarcoma viral oncogene homolog; EGF; Epidermal Growth Factor; PDGF; Platelet Derived
Systemic PTEN-Akt1-mTOR pathway activity in patients with normal tension glaucoma and ocular hypertension: A case series
Keywords: Normal tension glaucoma; Ocular hypertension; PTEN; Akt1; 4EBP1; S6K; mTOR; Mitochondria;
SPOCK1 promotes the growth of Osteosarcoma cells through mTOR-S6K signaling pathway
Keywords: SPOCK1; Osteosarcoma; mTOR; S6K; Cell growth;
p21-activated kinase 4 regulates HIF-1α translation in cancer cells
Keywords: Pak4; HIF-1α; Hypoxia; Akt; mTOR; 4E-BP1; Pak; p21-activated kinase; HIF; hypoxia-inducible factor; PHD; prolyl hydroxylase domain-containing protein; FBS; fetal bovine serum; HRE; hypoxia response element; PGK-1; phosphoglycerate kinase-1; DFO; desferri
SVCT-2 determines the sensitivity to ascorbate-induced cell death in cholangiocarcinoma cell lines and patient derived xenografts
Keywords: Ascorbic acid; Cholangiocarcinoma; ROS; SVCT-2; CC; cholangiocarcinoma; AA; ascorbic acid; ROS; reactive oxygen species; SVCT; sodium-dependent vitamin C transporter; NAC; N-acetyl-l-cysteine; CI; combination index; H2AX; histone 2AX; AMPK; adenosine mono
Different functions of DEPTOR in modulating sensitivity to chemotherapy for esophageal squamous cell carcinoma
Keywords: ESCC; esophageal squamous cell carcinoma; DEPTOR; DEP domain-containing mTOR-interacting protein; S6K; S6 kinase; mTOR; mammalian target of rapamycin; TNBC; triple negative breast cancer; NC; negative control; HE; hematoxylin and eosin; IHC; immunohistoch
Activation of the Tor/Myc signaling axis in intestinal stem and progenitor cells affects longevity, stress resistance and metabolism in drosophila
Keywords: AKH; adipokinetic hormone; CAFE; capillary feeding assay; DILP; Drosophila insulin-like peptide; EB; enteroblast; EC; enterocyte; EE; enteroendocrine cell; EGFR; epidermal growth factor receptor; ISC; intestinal stem cell; JAK/STAT; Janus kinase and signa
Effects of methimazole on Drosophila glucolipid metabolism in vitro and in vivo
Keywords: MMI; methimazole; P450s; cytochrome P450 enzymes; FMOs; flavin-containing monooxygenases; Dmfmos; Drosophila melanogaster flavin-containg monooxygenase 1 and 2; s6k; ribosomal protein S6 kinase; fas; fatty acid synthase; acc; acetyl-CoA carboxylase; cpt;
The role of the TOR pathway in mediating the link between nutrition and longevity
Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway
Keywords: FXR; mTOR/S6K; Liver cancer cells; Proliferation; AP; Ammonium peroxydisulfate; Acr-Bis; Acrylamide-bisacrylamide; BCA; Bicinchoninic acid; BLAST; Basic Local Alignment Search Tool; BSA; Bovine serum albumin; DEPC; Diethypyrocarbonate; DMSO; Dimethyl sulf
The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
Keywords: PKC; protein kinase C; IPC; ischemic pre conditioning; RACK; receptor for activated C-kinase; DAG; diacylglycerol; beta COP; coatomer subunit beta; CHOK1; chinese hamster ovary K1; CVD; cardiovascular disease; mKATP; ATP-sensitive mitochondrial potassium
Rosmarinic acid stimulates liver regeneration through the mTOR pathway
Keywords: Liver regeneration; Rosmarinic acid; mTOR; Rosemary; Proliferation; Partial hepatectomy; RA; Rosmarinic acid; PH; Partial hepatectomy; PI3K; Phosphoinositide-3 kinase; mTOR; Mammalian target of rapamycin; S6K; S6 protein kinase 1; PCNA; Proliferating cell
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro
Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats
Keywords: STZ; streptozotocin; PDN; painful diabetic neuropathy; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; S6K; ribosomal protein S6 kinase; 4E-BP; eukaryotic initiation factor 4E (eIF4E) binding protein; IR; insulin receptor; IRS-1; insulin r
Uroguanylin modulates (Na+Â +Â K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways
Keywords: UGN; uroguanylin; PT; proximal tubule; GFR; glomerular flow rate; NHE3; Na+/H+ exchanger isoform 3; PKA; protein kinase A; PKG; protein kinase G; Gi; inhibitory G protein; PKB; protein kinase B; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1;
Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation
Keywords: Mammalian target of rapamycin; Hippocampus; Kaplan-Meier; Forebrain-specific Tsc2 Knock-out; mTOR overactivation; mTORC; mechanistic Target of Rapamycin Complex; Rheb; Ras-homolog enriched in brain; S6; ribosomal protein S6; S6K; ribosomal protein S6 ki
A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ
Keywords: 4E-BP1; eukaryotic translation initiation factor 4E-binding protein; BMDM; bone marrow-derived macrophage; CM; conditioned medium; DMEM; Dulbecco's modified essential medium; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylen
Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
Keywords: mTOR; Rapamycin; Rb; TGF-β; eIF4E; 4E-BP1; eIF4E-binding protein-1; CDK; cyclin-dependent kinase; eIF4E; eukaryotic initiation factor 4E; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; S6K; S6 kinase; TGF-β; transforming growth factor-β;
The race to decipher the top secrets of TOP mRNAs
Keywords: TOP mRNAs; S6K; 4E-BP; TIA-1; LARP1; miR-10a
Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway
Keywords: 4E-BP; eukaryotic translation initiation factor 4E-binding protein; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AMPK; 5â² AMP-activated protein kinase; EBs; enteroblasts; ECs; enterocytes; EEs; enteroendocrine cells; EGFR; epidermal growth factor receptor; IGF1
Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: A tale of two complexes
Keywords: mTOR; mTORC1; mTORC2; S6K; 4E-BP1; GBM;
CCN1 acutely increases nitric oxide production via integrin αvβ3-Akt-S6K-phosphorylation of endothelial nitric oxide synthase at the serine 1177 signaling axis
Keywords: Endothelial nitric oxide synthase; Nitric oxide; Phosphorylation; CCN1; Integrin; Akt; S6K; Vasodilation; Free radicals;
Knockdown expression of eukaryotic initiation factor 5 C-terminal domain containing protein extends lifespan in Drosophila melanogaster
Keywords: ECP/KRA; AMPK; AKT; S6K; Longevity; Drosophila melanogaster;
Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent
Keywords: 4-HNE; 4-hydroxynonenal; cran; cranberry; IR; inverted repeat; MAPK; MAP kinase; RNAi; RNA interference; S6K; S6 kinase; SOD1; superoxide dismutase 1; SOD2; superoxide dismutase 2; SY; sugar-yeast diet; TOR; target of rapamycin; Aging; Dietary interventio
Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014
Keywords: 3-MA; 3-methyaldenine; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; mTOR; mammalian target or rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; S6K; p70-S6 Kinase 1; LC3B; light chain 3B; Colorectal cancer; AZD-2014; mTOR complexes;
Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components
Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling
Keywords: ANOVA; analysis of variance; CUL7; Cullin7; CRL7; Cullin RING E3 ubiquitin ligase 7; FBXW8; F-box/WD repeat-containing protein 8; GLUT4; glucose transporter 4; HSP90; heat shock protein 90; IRS; insulin receptor substrate; IGF-1; insulin-like growth hormo
Activation of Akt involves resistance to NF-κB inhibition and abrogation of both triggers synergistic apoptosis in lung adenocarcinoma cells
Keywords: Lung adenocarcinoma; NF-κB; Akt; S6K; DHMEQ; Rapamycin;
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells
Keywords: MDC; monodansylcadaverine; PASMC; pulmonary arterial smooth muscle cells; 5-HT; 5-hydroxytryptamine (serotonin); SERT; serotonin transporter; TG2; transglutaminase 2 aka tissue transglutaminase; Transglutaminase 2; AKT; S6K; S6; Serotonin; SERT;
Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle
Keywords: eEF1; eukaryotic elongation factor 1; eEF1A; eukaryotic elongation factor 1A; eEF1B; eukaryotic elongation factor 1B; eEF1Bγ; eukaryotic elongation factor 1γ; eEF1Bα; eukaryotic elongation factor 1α; eEF1Bδ; eukaryotic elongation factor 1Bδ; EEF1D;