کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8269907 1534967 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Monoamine oxidase inhibition prevents mitochondrial dysfunction and apoptosis in myoblasts from patients with collagen VI myopathies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Monoamine oxidase inhibition prevents mitochondrial dysfunction and apoptosis in myoblasts from patients with collagen VI myopathies
چکیده انگلیسی
Scheme of the pathway leading from Collagen VI deficiency to loss of cell viability through MAO-dependent ROS formation. The present study in human myoblasts demonstrated the role of MAO in oxidative stress and mitochondrial dysfunction confirming evidence obtained previously in mouse models of muscular dystrophy. In those models we documented also the oxidation of myofibrillar proteins that are involved in contractile impairment of viable myocites.110
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 75, October 2014, Pages 40-47
نویسندگان
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