کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8270996 | 1534979 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Iron-induced oxidation of (all-E)-β-carotene under model gastric conditions: kinetics, products, and mechanism
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
The stability of (all-E)-β-carotene toward dietary iron was studied in a mildly acidic (pH 4) micellar solution as a simple model of the postprandial gastric conditions. The oxidation was initiated by free iron (FeII, FeIII) or by heme iron (metmyoglobin, MbFeIII). FeII and metmyoglobin were much more efficient than FeIII at initiating β-carotene oxidation. Whatever the initiator, hydrogen peroxide did not accumulate. Moreover, β-carotene markedly inhibited the conversion of FeII into FeIII. β-Carotene oxidation induced by FeII or MbFeIII was maximal with 5-10 eq FeII or 0.05-0.1 eq MbFeIII and was inhibited at higher iron concentrations, especially with FeII. UPLC/DAD/MS and GC/MS analyses revealed a complex distribution of β-carotene-derived products including Z-isomers, epoxides, and cleavage products of various chain lengths. Finally, the mechanism of iron-induced β-carotene oxidation is discussed. Altogether, our results suggest that dietary iron, especially free (loosely bound) FeII and heme iron, may efficiently induce β-carotene autoxidation within the upper digestive tract, thereby limiting its supply to tissues (bioavailability) and consequently its biological activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 63, October 2013, Pages 195-206
Journal: Free Radical Biology and Medicine - Volume 63, October 2013, Pages 195-206
نویسندگان
Charlotte Sy, Olivier Dangles, Patrick Borel, Catherine Caris-Veyrat,