کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8292637 | 1536736 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons The endogenous agonist, β-alanine, activates glycine receptors in rat spinal dorsal neurons](/preview/png/8292637.png)
چکیده انگلیسی
β-alanine is a structural analog of glycine and γ-aminobutyric acid (GABA) and is thought to be involved in the modulation of nociceptive information at the spinal cord. However, it is not known whether β-alanine exerts its effect in substantia gelatinosa (SG) neurons of the spinal dorsal horn, where glycine and GABA play an important role in regulating nociceptive transmission from the periphery. Here, we investigated the effects of β-alanine on inhibitory synaptic transmission in adult rat SG neurons using whole-cell patch-clamp. β-alanine dose-dependently induced outward currents in SG neurons. Current-voltage plots revealed a reversal potential at approximately â70â¯mV, which was close to the equilibrium potential of Clâ. Pharmacological analysis revealed that β-alanine activates glycine receptors, but not GABAA receptors. These results suggest that β-alanine hyperpolarizes the membrane potential of SG neurons by activating Clâ channels through glycine receptors. Our findings raise the possibility that β-alanine may modulate pain sensation through glycine receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 4, 12 June 2018, Pages 897-901
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 4, 12 June 2018, Pages 897-901
نویسندگان
Yutaka Seino, Nobuko Ohashi, Tatsuro Kohno,