کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8292714 1536737 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death
چکیده انگلیسی
Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts. However, in SK2−/− cells, SK1 expression was markedly increased to SK2 levels whereas in SK1−/− cells, SK2 expression was unaffected. Ceramide, glucosylceramide and sphingosine levels were all increased in SK1−/− but less so in SK2−/− cells and S1P levels were not significantly reduced in either SK1−/− or SK2−/− cells. Greatly increased Ceramide glucosyltransferase expression was observed in SK1−/− cells but less so in SK2−/− cells suggested a role in drug resistance. SK2−/− cells grew faster than control and SK1−/−. The cell division gene PCNA was significantly overexpressed in SK2−/− cells, suggesting a cross regulation between SKs and Ceramide glucosyltransferase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 500, Issue 3, 7 June 2018, Pages 597-602
نویسندگان
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