First-line anti-tuberculosis drugs induce hepatotoxicity: A novel mechanism based on a urinary metabolomics platform

With the application of UPLC-MS based metabolomics, the tricarboxylic acid circulation, arginine and proline metabolism and purine metabolic pathways were found to be affected by anti-TB drugs, xanthine oxidase may significantly contribute to the generation of superoxides for aggravating hepatotoxic effects in the metabolism of PZA and endogenous metabolites indicating that our metabolomic approach had the ability to predict first-line anti-tuberculosis drugs induce hepatotoxicity for clinical applications.209