A structural model of the HIV-1 Rev-integrase complex: The molecular basis of integrase regulation by Rev

► The Rev and integrase (IN) proteins of the HIV-1 interact with each other. ► Rev inhibits IN and by that limits the integration events to 1-2 per cell. ► Inhibition of the Rev-IN interaction leads to apoptosis of HIV-1 infected cells. ► We describe a structural docking model for the Rev-IN complex. ► In binds the Rev monomer via two distinct binding interfaces.