کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8299328 1537129 2018 33 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanism of aggregation and membrane interactions of mammalian prion protein
ترجمه فارسی عنوان
مکانیسم تجمع و تعامل غشاء پروتئین پریون پستان
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
The cellular prion protein (PrPC), which is present ubiquitously in all mammalian neurons, is normally found to be linked to the cell membrane through a glycosylphosphatidylinositol (GPI) anchor. The conformational conversion of PrPC into misfolded and aggregated forms is associated with transmissible neurodegenerative diseases known as prion diseases. The importance of different misfolded conformations in prion diseases, and the mechanism by which prion aggregates induce neurotoxicity remain poorly understood. Multiple studies have been shown that the toxicity of misfolded prion protein is directly correlated with its ability to interact with and perturb membranes. This review describes the current progress toward understanding prion protein misfolding and aggregation, as well as the interaction of prion protein aggregates with lipid membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1860, Issue 9, September 2018, Pages 1927-1935
نویسندگان
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