Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: A key role for hRFT-2 in intestinal riboflavin uptake

► This study provides evidence for the importance of hRFT-2 in normal intestinal riboflavin absorption. ► The study also identifies which membrane domain of polarized epithelia the hRFT-1, -2 and -3 transporters are expressed. ► hRFT-2 is the most active and predominantly expressed RFT in normal intestine.