کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8309680 | 1538621 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Single nucleotide polymorphisms of microRNA in cardiovascular diseases
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کلمات کلیدی
CHDHRMACSDCMAmI - AMIMyocardial infarction - آنفارکتوس میوکاردCoronary restenosis - استراحت کرونرcoronary artery disease - بیماری عروق کرونرcoronary heart disease - بیماری عروق کرونر قلبcardiovascular disease - بیماری قلب و عروقیCongenital heart disease - بیماری قلبی مادرزادیPCR-RFLP - روش PCR-RFLPAcute coronary syndrome - سندرم کرونری حادAcute myocardial infarction - سکته قلبیCAD - طراحی به کمک رایانه یا کَدMiRNA - میکروRNA، ریزآرانای، miRNApolymerase chain reaction-restriction fragment length polymorphism - پلیمورفیسم طول قطعه واکنش زنجیره پلیمرازDilated cardiomyopathy - کاردیومیوپاتی دیلاته، کاردیومیوپاتی کامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Despite the advances in medicine and in science of diagnosis, cardiovascular diseases (CVD) remain the number one cause of morbidity and mortality worldwide. Apart from the modifiable risk factors, genetic factors are believed to also influence the outcome of this umbrella of diseases. Under the genetic factors, miRNA polymorphisms, namely miR-146a (rs2910164), miR-196 (rs11614913) and miR-499 (rs3746444), have become an important tool to study the mechanism that underlie the pathogenesis of this disease. In this review, we analyze the advances made through various research studies and the evidence provided by them in the area of miRNA polymorphisms by comparing the allelic frequencies and genotyping patterns. Interestingly, these studies have contradicting results even those conducted in same set of population. We also highlight the gap in literature search as majority of these studies have been conducted in Chinese population and data gaps are evident in Caucasian population, along with developing countries like, India, where no such data is available. This makes the daunting task of presenting a global picture and of the extent these polymorphisms play a role in CVD progression, even more difficult. Therefore, we suggest that more work needs to be done by taking various geographical domains in to consideration. Also, larger sample size calculated through statistical tools is the key to progress in establishing the genetic co-relation of miRNA polymorphisms and CVDs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 478, March 2018, Pages 101-110
Journal: Clinica Chimica Acta - Volume 478, March 2018, Pages 101-110
نویسندگان
Kamna Srivastava, Kirti Tyagi,