ONTD induces apoptosis of human hepatoma Bel-7402 cells via a MAPK-dependent mitochondrial pathway and the depletion of intracellular glutathione

- ONTD inhibits the viability and the growth of human hepatoma cells.
- ONTD increases ROS production and reduces intracellular GSH.
- ONTD triggers mitochondrial-related apoptosis in Bel-7402 cells.
- MAPKs signaling activation contributes to ONTD-induced apoptosis.
- Antioxidants attenuates the induction of apoptosis caused by ONTD in Bel-7402 cells.