Flaxseed oil rich in omega-3 protects aorta against inflammation and endoplasmic reticulum stress partially mediated by GPR120 receptor in obese, diabetic and dyslipidemic mice models

(A) Toll-like receptor pathway. (B) Tumoral necrosis factor-receptor pathway. (C) Alpha linolenic fatty acid (ALA) binding in GPR120 (black arrow); probably binding in GPR40 and GPR119 (white arrows) and its incorporation in cell membrane (yellow phospholipids). Segmented lines show inflammatory pathways partially blocked by GPR120/β-arrestin2 pathway.203