کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8336447 | 1540616 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology
ترجمه فارسی عنوان
اسیدهای چرب امگا -3 و امگا 6 سبب پوکی استخوان می شوند
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کلمات کلیدی
EPAColony forming unit-granulocyte-macrophageNAFLDEMHCFU-GMOROMCVMUFAEMMNon-alcoholic steatohepatitis - استئاتوهپاتیت غیرالکلیArachidonic acid - اسید آراشیدونیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکperiodic acid–Schiff - اسید فسفریک SchiffFatty acid - اسید چربmonounsaturated fatty acid - اسید چرب غیر اشباعnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیMean corpuscular volume - حجم متوسط مایعExtramedullary hematopoiesis - خونریزی ExtramedullaryDHA - دوکوساهگزائنوئیک اسیدOil red O - روغن قرمز Olong chain - زنجیره طولانیPAS - نهNash - نوش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Recent evidence has suggested that dietary polyunsaturated fatty acids (PUFAs) modulate inflammation; however, few studies have focused on the pathobiology of PUFA using isocaloric and isolipidic diets and it is unclear if the associated pathologies are due to dietary PUFA composition, lipid metabolism or obesity, as most studies compare diets fed ad libitum. Our studies used isocaloric and isolipidic liquid diets (35% of calories from fat), with differing compositions of omega (Ï)-6 or long chain (Lc) Ï-3 PUFA that were pair-fed and assessed hepatic pathology, inflammation and lipid metabolism. Consistent with an isocaloric, pair-fed model we observed no significant difference in diet consumption between the groups. In contrast, the body and liver weight, total lipid level and abdominal fat deposits were significantly higher in mice fed an Ï-6 diet. An analysis of the fatty acid profile in plasma and liver showed that mice on the Ï-6 diet had significantly more arachidonic acid (AA) in the plasma and liver, whereas, in these mice Ï-3 fatty acids such as eicosapentaenoic acid (EPA) were not detected and docosahexaenoic acid (DHA) was significantly lower. Histopathologic analyses documented that mice on the Ï-6 diet had a significant increase in macrovesicular steatosis, extramedullary myelopoiesis (EMM), apoptotic hepatocytes and decreased glycogen storage in lobular hepatocytes, and hepatocyte proliferation relative to mice fed the Lc Ï-3 diet. Together, these results support PUFA dietary regulation of hepatic pathology and inflammation with implications for enteral feeding regulation of steatosis and other hepatic lesions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 52, February 2018, Pages 92-102
Journal: The Journal of Nutritional Biochemistry - Volume 52, February 2018, Pages 92-102
نویسندگان
Saraswoti Khadge, John Graham Sharp, Geoffrey M. Thiele, Timothy R. McGuire, Lynell W. Klassen, Michael J. Duryee, Holly C. Britton, Alicia J. Dafferner, Jordan Beck, Paul N. Black, Concetta C. DiRusso, James Talmadge,