کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337233 | 1540666 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells
ترجمه فارسی عنوان
اثرات اسیدهای چرب رژیم در محور گیرنده لیپوپروتئین / آپوبرامای غنی از تری گلیسیرید در سلول های مونوسیت / ماکروفاژ انسانی
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کلمات کلیدی
ROORPLP09cRA9-Cis-retinoic acidHPSOTRLRXRHprtRetinoid X receptorPPARABCA1LBPPhorbol 12-myristate-13-acetateribosomal protein large P0LBDqRT-PCRSFAACATMUFAacyl-CoA:cholesterol acyltransferase - acyl-CoA: کلسترول آتیل ترانسفرازATP-binding cassette transporter A1 - ATP اتصال گیرنده کاست A1PMA - LDC هاSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAPPRE - ارسالsaturated fatty acids - اسیدهای چرب اشباع شدهmonounsaturated fatty acids - اسیدهای چرب غیر اشباعLigand binding pocket - جیب گیرنده لیگندligand binding domain - دامنه اتصال لیگاندOlive oil - روغن زیتونtriglyceride-rich lipoproteins - لیپوپروتئین های غنی از تری گلیسیریدMacrophages - ماکروفاژها،درشت خوارهاMonocytes - مونوسیتهاhypoxanthine phosphoribosyltransferase - هیپوکسانتین فسفریبوسیل ترانسفرازquantitative reverse transcription polymerase chain reaction - واکنش زنجیره ای پلی مراز رونویسی معکوس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Intestinally produced triglyceride-rich lipoproteins (TRL) play an important role in the progression of atherosclerosis. In this study, we investigated the relevance of monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA) in postprandial TRL in affecting the transcriptional activity of the apolipoprotein-B48 receptor (ApoB48R) and its functionality in human monocyte/macrophage cells. Healthy male volunteers were administered four standardized high-fat meals containing butter, high-palmitic sunflower oil, olive oil (ROO) or a mixture of vegetable and fish oils (50 g/m2 body surface area) to obtain a panel of postprandial TRL with gradual MUFA oleic acid-to-SFA palmitic acid ratios. The increase in this ratio was linearly associated with a decrease of ApoB48R up-regulation and lipid accumulation in THP-1 and primary monocytes. ApoB48R mRNA levels and intracellular triglycerides were also lower in the monocytes from volunteers after the ingestion of the ROO meal when compared to the ingestion of the butter meal. In THP-1 macrophages, the increase in the MUFA oleic acid-to-SFA palmitic acid ratio in the postprandial TRL was linearly correlated with an increase in ApoB48R down-regulation and a decrease in lipid accumulation. We also revealed that the nuclear receptor transcription factors PPARα, PPARβ/δ, and PPARγ and the PPAR-RXR transcriptional complex were involved in sensing the proportion of MUFA oleic acid and SFA palmitic acid, and these were also involved in adjusting the transcriptional activity of ApoB48R. The results of this study support the notion that MUFA-rich dietary fats may prevent excessive lipid accumulation in monocyte/macrophage cells by targeting the postprandial TRL/ApoB48R axis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 12, December 2013, Pages 2031-2039
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 12, December 2013, Pages 2031-2039
نویسندگان
Lourdes M. Varela, Almudena Ortega-Gomez, Sergio Lopez, Rocio Abia, Francisco J.G. Muriana, Beatriz Bermudez,