کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8337379 | 1540671 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver
ترجمه فارسی عنوان
پس از 48 ساعت سریع رعایت یک رژیم استاندارد، پاسخ التهابی را در کبد ماوس نشان می دهد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NF-κBHMGB1ATF3CXCLTLRGRP94A20GLUT2ALTRefeedingICAM-1GAPDHHSPD1AST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازtumor necrosis factor-α - تومور نکروز عامل αToll-like receptor - تیالآرFasting - روزه داریTNF-α - فاکتور نکروز توموری آلفاnuclear factor κB - فاکتور هسته ای κBactivating transcription factor 3 - فعال کردن عامل رونویسی 3chemokine (C-X-C motif) ligand - لیکوئید کوموکین (C-X-C motif)Endogenous ligand - لیگاند اندوژنintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1Inflammatory mediator - واسطه التهابیglucose-regulated protein 94 - پروتئین تنظیم شده با گلوکز 94High mobility group box 1 - کادر تحرک بالا 1Carbohydrate - کربوهیدراتglucose transporter 2 - گلوکز 2glyceraldehydes-3-phosphate dehydrogenase - گلیسرالید هیدروژن 3-فسفات دهیدروژنازToll-like receptor 2 - گیرنده تله مانند 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Unhealthy eating behaviors increase the risk of metabolic diseases, but the underlying mechanisms are not fully elucidated. Because inflammation contributes to the pathogenesis of metabolic diseases, it is important to understand the effects of unhealthy eating on the inflammatory state. The objective of our present study was to address the effects of a fasting-refeeding regime, a model of irregular eating, on the hepatic inflammatory responses in mouse. The animals were fasted for 48 h and then refed either a standard or low-carbohydrate/high-fat diet. Inflammatory gene expression in the liver was then sequentially measured for the first 17 h after initiation of refeeding. To assess the roles of dietary carbohydrates and toll-like receptor 2 (TLR2) in the refeeding-induced inflammatory changes, gene expression levels in mice refed only carbohydrates (α-corn starch and sucrose) at different doses and in TLR2-deficient mice refed a standard diet were also analyzed. Refeeding with a standard diet increased the liver expression of Tlr2, proinflammatory mediators (Cxcl10, Cxcl1, Cxcl2, Icam-1) and negative regulators of TLR-signaling (A20 and Atf3). These increases were attenuated in mice refed a low-carbohydrate/high-fat diet. Refeeding only α-corn starch and sucrose also increased the expression of these inflammatory pathway genes depending on the doses. TLR2 deficiency significantly attenuated the refeeding-induced increase in the liver expression of Cxcl10, Cxcl1, Icam-1 and A20. These findings suggest that an irregular eating behavior can elicit a liver inflammatory response, which is at least partly mediated by TLR2, and that dietary carbohydrates play critical roles in this process.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 7, July 2013, Pages 1314-1323
Journal: The Journal of Nutritional Biochemistry - Volume 24, Issue 7, July 2013, Pages 1314-1323
نویسندگان
Motoko Oarada, Takashi Miki, Shohei Kohno, Kanae Sakai, Takeshi Nikawa, Mitsutoshi Yoneyama, Tohru Gonoi,