کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8358926 | 1542169 | 2016 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids
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کلمات کلیدی
DCAALACLADCWYarrowia lipolyticaEPAGEMs - GEM هاeicosapentanoic acid - اسید ایکوزاپنتانوئیکDocosahexanoic acid - اسید داکوساگزناکRicinoleic acid - اسید ریسینولیکLinoleic acid - اسید لینولئیکUnusual fatty acids - اسیدهای چرب غیر معمولMetabolic flux analysis - تجزیه و تحلیل شار متابولیکtriacylglycerol - تری آسیل گلیسرول TAG یا triacylglycerols - تری گلیسرید یا تری آسیل گلیسرولDHA - دوکوساهگزائنوئیک اسیدdiacylglycerol - دیسیل گلیسیرینDAG - روزSystems metabolic engineering - سیستم متابولیک مهندسی سیستمLipid metabolism - متابولیسم لیپیدOleaginous yeasts - مخمرهای شیریMFA - وزارت امور خارجهdry cell weight - وزن سلول خشک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
One of the most promising alternatives to petroleum for the production of fuels and chemicals is bio-oil based chemistry. Microbial oils are gaining importance because they can be engineered to accumulate lipids enriched in desired fatty acids. These specific lipids are closer to the commercialized product, therefore reducing pollutants and costly chemical steps. Yarrowia lipolytica is the most widely studied and engineered oleaginous yeast. Different molecular and bioinformatics tools permit systems metabolic engineering strategies in this yeast, which can produce usual and unusual fatty acids. Usual fatty acids, those usually found in triacylglycerol, accumulate through the action of several pathways, such as fatty acid/triacylglycerol synthesis, transport and degradation. Unusual fatty acids are enzymatic modifications of usual fatty acids to produce compounds that are not naturally synthetized in the host. Recently, the metabolic engineering of microorganisms has produced different unusual fatty acids, such as building block ricinoleic acid and nutraceuticals such as conjugated linoleic acid or polyunsaturated fatty acids. Additionally, microbial sources are preferred hosts for the production of fatty acid-derived compounds such as γ-decalactone, hexanal and dicarboxylic acids. The variety of lipids produced by oleaginous microorganisms is expected to rise in the coming years to cope with the increasing demand.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Lipid Research - Volume 61, January 2016, Pages 40-50
Journal: Progress in Lipid Research - Volume 61, January 2016, Pages 40-50
نویسندگان
Rodrigo Ledesma-Amaro, Jean-Marc Nicaud,