کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8450321 1547683 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials
چکیده انگلیسی
Chimeric antigen receptor (CAR) T cell therapy is anticipated to be increasingly implemented in the context of cancer treatment after two current FDA approval of anti-CD19 CAR-T cells (Kymriah™ & Yescarta™). The success of CD19 is mainly attributable to the proper selection of the antigen, CD19, as the target of the disease, highlighting the importance of target selection for other CAR therapies. Therefore, here we performed a global analysis of targets that are the prime focus for various CAR T cell therapies in human clinical trials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 369, Issue 1, 1 August 2018, Pages 1-10
نویسندگان
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