کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8451198 | 1547693 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma](/preview/png/8451198.png)
چکیده انگلیسی
Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy. CC treatment options are very limited especially for patients with distant metastasis. Kangai 1 C-terminal interacting tetraspanin (KITENIN) is highly expressed in numerous cancers, but the role of KITENIN in CC remains unknown. Here, we have investigated for the first time the function of KITENIN in human CC cell lines (TFK-1, SZ-1), tissues and a CC mouse model (Alb-Cre/LSL-KRASG12D/p53L/L). KITENIN was expressed in 92.2% of human CC tissues, in murine CC samples and also in human CC cell lines. Knockdown of KITENIN by small interfering RNA (siRNA) effectively reduced proliferation, migration, invasion and colony formation in both intra- and extra-hepatic CC cells. The expression of epithelial-mesenchymal transition (EMT) markers like N-cadherin, Vimentin, Snail and Slug were suppressed in KITENIN knockdown CC cells. Our results indicate that KITENIN is crucial for cholangiocarcinogenesis and it might become a potential therapeutic target for human CC treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 364, Issue 1, 1 March 2018, Pages 59-67
Journal: Experimental Cell Research - Volume 364, Issue 1, 1 March 2018, Pages 59-67
نویسندگان
Khac Cuong Bui, Samarpita Barat, Xi Chen, Przemyslaw Bozko, Tim Scholta, Mai Ly Thi Nguyen, Vikas Bhuria, Jun Xing, Linh Toan Nguyen, Huu Song Le, Thirumalaisamy P. Velavan, Bence Sipos, Ludwig Wilkens, Nisar P. Malek, Ruben R. Plentz,