کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8452093 | 1547700 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of non-small cell lung cancer microenvironment indicates preponderance of T cell exhaustion marker expression
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کلمات کلیدی
PD-1CFSECTLA4LAG3Lung cancer - سرطان ریهT cell - سلول تیMicroenvironment - میکرو محیطcytotoxic T-lymphocyte-associated protein 4 - پروتئین مرتبط با لنفوسیت T تری سیتوتوکسی 4programmed cell death protein 1 - پروتئین مرگ سلولی برنامه ریزی شده 1carboxyfluorescein succinimidyl ester - کربوکسیفلوورسسین سوکسینیمیدیل استر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Lung cancer metastasis causes 70% of an estimated 1.4 million deaths per annum. The major shortcoming in lung cancer is the tendency to have inherent or develop acquired resistance to chemotherapy. It is now evolving that such resistance might develop due to differential contribution and interaction with tumor microenvironment, stromal cells, and the extracellular matrix. The objective of the current study was to define the lung cancer tumor microenvironment. We have identified multiple tumor-infiltrating T lymphocyte subsets in patients with lung cancer, which were independent of disease stage. Functional analysis indicated high expression of the inhibitory receptors, cytotoxic T-lymphocyte-associated protein 4 (CTLA4), lymphocyte activated gene 3 (LAG3) and programmed cell death protein 1 (PD-1) in both CD4 and CD8 subsets, compared to non-malignant controls. Inhibitory receptors expressed by the tumor infiltrating T cells might mediate tolerance to tumor antigens with co-expression of these receptors exacerbating lung carcinogenesis and metastatic progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 360, Issue 2, 15 November 2017, Pages 205-209
Journal: Experimental Cell Research - Volume 360, Issue 2, 15 November 2017, Pages 205-209
نویسندگان
Hui Zhou, Tingwei Liu, Zanfeng Wang,