CaV1.2 signaling complexes in the heart

► Ca2 + influx by L-type Ca2 + channels trigger Ca2 + release and cardiac contraction. ► We discuss how VGCC are regulated by GPCR via cAMP/PKA. ► VGCC form signaling complexes with β2AR, Gs, adenylyl cyclase, and PKA. ► VGCC also associate with the protein phosphatases PP2A and PP2B. ► These complexes regulate channel activity in a highly localized manner.