Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

► Expression of STX1A, SYT4, SYT7, SYT11 and SYT13 is reduced in islets from human T2D donors. ► Expression of STX1A, SYT4, SYT7, SYT11, SYT13, SNAP25 and STXBP1 correlates positively with GSIS. ► Expression of STX1A, SYT4, SYT7, SYT11, SYT13, SNAP25 and STXBP1 correlates negatively to HbA1c. ► Reduced expression of exocytotic genes contribute to impaired insulin secretion.