کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8485438 1551737 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lack of impact of rotavirus vaccination on childhood seizure hospitalizations in England - An interrupted time series analysis
ترجمه فارسی عنوان
عدم تاثیر واکسیناسیون روتاویروس در بستری شدن در تشنج های دوران کودکی در انگلستان - تحلیل سری زمانی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Observational studies have linked a reduction in childhood seizures (CS) to the introduction of rotavirus vaccination (RV). England is opportunely placed to explore this due to well-defined introduction, high uptake of RV and centralised Hospital Episodes Statistics recording all admissions. We investigated the association between seizures and vaccine use through interrupted time-series analysis of all CS admissions in children <3 years old (ICD-10 codes; G40∗-G41∗, R56.0∗) during 2007-2017. We did not detect a statistically significant association between the introduction of RV and admission with febrile (p = 0.84), afebrile (p = 0.83) or all CS (p = 0.93), even when limited to peak rotavirus seasonality (March). This is the first ecological study in a country that exclusively uses the monovalent vaccine. Although a negative finding, we would argue that if an effect cannot be detected at this population level then it is unlikely to be clinically or economically significant but generates hypotheses of potential non-specific effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 36, Issue 31, 25 July 2018, Pages 4589-4592
نویسندگان
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