کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8485905 | 1551756 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Vaccination against influenza is widely used to protect against seasonal flu epidemic although its effectiveness is debated. Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 36, Issue 12, 14 March 2018, Pages 1599-1605
Journal: Vaccine - Volume 36, Issue 12, 14 March 2018, Pages 1599-1605
نویسندگان
Anastasiia L. Sycheva, Mikhail V. Pogorelyy, Ekaterina A. Komech, Anastasia A. Minervina, Ivan V. Zvyagin, Dmitriy B. Staroverov, Dmitriy M. Chudakov, Yuri B. Lebedev, Ilgar Z. Mamedov,