A phase 3, randomized, double-blind trial comparing the safety and immunogenicity of the 7-valent and 13-valent pneumococcal conjugate vaccines, given with routine pediatric vaccinations, in healthy infants in Brazil

► Phase 3 trial of PCV7 and PCV13 with routine vaccines in Brazilian infants. ► PCV7 and PCV13 had comparable immunogenicity for the PCV7 serotypes. ► PCV13 had higher immunogenicity for the 6 additional serotypes in PCV13. ► The two pneumococcal conjugate vaccines had comparable safety profiles. ► No interference with concomitant whole-cell pertussis vaccine.