Effectiveness and cost-effectiveness of pediatric rotavirus vaccination in British Columbia: A model-based evaluation

► The cost-effectiveness of novel rotavirus vaccines is uncertain in the Canadian context. ► An economic analysis was performed for rotavirus vaccine preparations in Canada. ► A monovalent vaccine (Rotarix) was highly cost-effective. ► A pentavalent vaccine (RotaTeq) was less effective and cost more, and was “dominated”. ► Findings remained robust in the face of wide-ranging sensitivity and uncertainty analyses.