کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8495508 | 1552867 | 2013 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeted dietary micronutrient fortification modulates n â 3 LC-PUFA pathway activity in rainbow trout (Oncorhynchus mykiss)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
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![عکس صفحه اول مقاله: Targeted dietary micronutrient fortification modulates n â 3 LC-PUFA pathway activity in rainbow trout (Oncorhynchus mykiss) Targeted dietary micronutrient fortification modulates n â 3 LC-PUFA pathway activity in rainbow trout (Oncorhynchus mykiss)](/preview/png/8495508.png)
چکیده انگلیسی
Replacing fish oil (FO) in aquafeeds with sustainable alternatives such as vegetable oils (VO) compromises the content of n â 3 long-chain polyunsaturated fatty acid (n â 3 LC-PUFA) in the edible portions of farmed fish. Endogenous biosynthesis of n â 3 LC-PUFA from C18 precursors is catalysed by several enzymes, which have low activity in carnivorous fish. Rainbow trout were fed on VO-based diets supplemented with increasing levels of selected micronutrients as potential n â 3 LC-PUFA biosynthesis co-factors or coenzyme precursors: iron, zinc, magnesium, niacin, riboflavin, pyridoxine and biotin at 100, 200, 300 or 400% of their recommended dietary inclusion. Providing the substrate (ALA, 18:3n â 3) and the potential enzyme co-factors was assumed to enhance the efficiency of EPA (20:5n â 3) and DHA (22:6n â 3) production. Initial evidence was established when DHA and total n â 3 LC-PUFA content increased in the whole body of fish from the treatment with the highest micronutrient fortification. Fewer changes were observed in the fillet or liver which was consistent with a marginal regulation of the mRNA expression of key biosynthesis genes in the liver. The potential co-factors seem to stimulate the n â 3 LC-PUFA biosynthesis efficiency at the molecular and enzymatic level in rainbow trout fed on ALA-rich diet, leading to metabolic and chemical changes. The interactions between dietary substrate and enzyme co-factors/coenzymes need to be further investigated to advance lipid metabolism research and benefit the aquaculture industry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volumes 412â413, 1 November 2013, Pages 215-222
Journal: Aquaculture - Volumes 412â413, 1 November 2013, Pages 215-222
نویسندگان
Michael J. Lewis, Noor Khalidah Abdul Hamid, Ramez Alhazzaa, Karen Hermon, John A. Donald, Andrew J. Sinclair, Giovanni M. Turchini,