Efficacy of a freeze-dried aqueous extract of Nepeta menthoides Boiss. & Buhse in the treatment of anxiety in patients with depression: A double-blind, randomized, controlled trial

The anxiolytic effects of N. menthoides, its lower symptom recurrence rate and its lesser side effects make this herb a potential alternative treatment for anxiety in patients with depression. The presence of polyphenols and flavonoids in the extract might be at least partially responsible for these clinical effects.