کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513218 | 1556491 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Confirmation of More Stable Polymorphic Form of Etoricoxib at Room Temperature
ترجمه فارسی عنوان
تأیید فرم پلیمورفیک پایدار اتریکوکسیب در دمای اتاق
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Polymorphic forms of etoricoxib have been reported in the literature, and form I was considered to be the most stable one. However, in this work, it was found that form I and form V are enantiotropic by differential scanning calorimetry analysis, solubility measurements, and solution-mediated polymorphic transformation experiments with form V being more stable than form I at room temperature. Thermodynamic transition temperature is determined as (353.45 ± 0.10) K. Besides, form V would transform to form I with the seeding effect of form I at high temperature below the melting point of form V. The crystal structure of form V was solved for the first time. The molecules in form V are linked by weak hydrogen bond C-Hâ¯O to form ring motif, which is nonexistent in form I.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 7, July 2018, Pages 1903-1910
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 7, July 2018, Pages 1903-1910
نویسندگان
Ting Zhang, Liping Wang, Ying Bao, Qi Yang, Lina Zhou, Hongxun Hao, Chuang Xie,