کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514598 | 1556509 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mimicking the Impact of Infant Tongue Peristalsis on Behavior of Solid Oral Dosage Forms Administered During Breastfeeding
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کلمات کلیدی
APIPolyetheretherketoneTMSPediatric - اطفالOral drug delivery - تحویل داروی خوراکیPhysical characterization - خصوصیات فیزیکیPEEK - زیرچشمی نگاه کردنsulforhodamine B - سولفوردامین بDrug delivery systems - سیستم های تحویل داروin vitro models - مدل های in vitroActive Pharmaceutical Ingredient - مواد اولیه دارویی فعال
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
An in vitro simulation system was developed to study the effect of an infant's peristaltic tongue motion during breastfeeding on oral rapidly disintegrating tablets in the mouth, for use in rapid product candidate screening. These tablets are being designed for use inside a modified nipple shield worn by a mother during breastfeeding, a proposed novel platform technology to administer drugs and nutrients to breastfeeding infants. In this study, the release of a model compound, sulforhodamine B, from tablet formulations was studied under physiologically relevant forces induced by compression and rotation of a tongue mimic. The release profiles of the sulforhodamine B in flowing deionized water were found to be statistically different using 2-way ANOVA with matching, when tongue mimic rotation was introduced for 2 compression levels representing 2 tongue strengths (p = 0.0013 and p < 0.0001 for the lower and higher compression settings, respectively). Compression level was found to be a significant factor for increasing model compound release at rotational rates representing nonnutritive breastfeeding (p = 0.0162). This novel apparatus is the first to simulate the motion and pressures applied by the tongue and could be used in future infant oral product development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 1, January 2017, Pages 193-199
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 1, January 2017, Pages 193-199
نویسندگان
Rebekah L. Scheuerle, Richard A. Kendall, Catherine Tuleu, Nigel K.H. Slater, Stephen E. Gerrard,