The accelerated blood clearance phenomenon of PEGylated nanoemulsion upon cross administration with nanoemulsions modified with polyglycerin

The first dose of the 1,2-distea-royl-sn-glycero-3-phosphoethanolamine-n-polygly-cerine-610 modified nanoemulsions can induce the ABC phenomenon of the second dose of the PEGylated nanoemulsions. We synthesized polycarboxyl compound via the esterification reaction of 1,2-distea-royl-sn-glycero-3-phosphoethan-olamine-n-polyglycerine-610 and succinic anhydride. The polycarboxyl structure in the new modified compound we synthesized can circumvent the ABC phenomenon of the second dose of the PEGylated nanoemulsions.