کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8519035 | 1556730 | 2018 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Validation of kinetic modeling of progesterone release from polymeric membranes
ترجمه فارسی عنوان
اعتبار مدل سازی جنبشی از انتشار پروژسترون از غشاهای پلیمری
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کلمات کلیدی
مدل های ریاضی، اعتبار مدل، تحویل / انتشار مواد مخدر، ضریب انتقال توده، ثابت توزیع تعادل،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
چکیده انگلیسی
Mathematical modeling in drug release systems is fundamental in development and optimization of these systems, since it allows to predict drug release rates and to elucidate the physical transport mechanisms involved. In this paper we validate a novel mathematical model that describes progesterone (Prg) controlled release from poly-3-hydroxybutyric acid (PHB) membranes. A statistical analysis was conducted to compare the fitting of our model with six different models and the Akaike information criterion (AIC) was used to find the equation with best-fit. A simple relation between mass and drug released rate was found, which allows predicting the effect of Prg loads on the release behavior. Our proposed model was the one with minimum AIC value, and therefore it was the one that statistically fitted better the experimental data obtained for all the Prg loads tested. Furthermore, the initial release rate was calculated and therefore, the interface mass transfer coefficient estimated and the equilibrium distribution constant of Prg between the PHB and the release medium was also determined. The results lead us to conclude that our proposed model is the one which best fits the experimental data and can be successfully used to describe Prg drug release in PHB membranes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 13, Issue 1, January 2018, Pages 54-62
Journal: Asian Journal of Pharmaceutical Sciences - Volume 13, Issue 1, January 2018, Pages 54-62
نویسندگان
Analia Irma Romero, Mercedes Villegas, Alicia Graciela Cid, Mónica Liliana Parentis, Elio Emilio Gonzo, José MarÃa Bermúdez,