کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8522980 | 1557786 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS
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کلمات کلیدی
CARTChinese rhesus macaquesSIVIDODAMPPBMCMPO - DFOinflammation - التهاب( توروم) danger-associated molecular patterns - الگوهای مولکولی مرتبط با خطرAIDS - ایدزcombination antiretroviral therapy - درمان ضد رتروویروسی ترکیبیperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیacquired immunodeficiency syndrome - سندرم نقص ایمنی به دست آوردSiglec - سیگلکmyeloperoxidase - میلوپراکسیداز Human Immunodeficiency Virus type-1 - ویروس ایمنی بدن نوع 1HIV - ویروس نقص ایمنی انسانی Simian immunodeficiency virus - ویروس کمبود ایمنی سیمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chronic immune activation and systemic inflammation are underlying causes of acquired immunodeficiency syndrome (AIDS). Products of virus replication and microbial translocation, co-infection or opportunistic pathogens, and danger-associated molecular patterns have been reported to contribute to chronic immune activation and inflammation in human immunodeficiency virus type-1/simian immunodeficiency virus (HIV-1/SIV) infection or other disease. To develop new strategies and therapies for HIV-1/AIDS, we tested if the CD24 and Fc fusion protein (CD24Fc), which interacts with danger-associated molecular patterns and sialic acid binding Ig-like lectin to attenuate inflammation, can protect Chinese rhesus macaques (ChRMs) with SIV infection. We found that CD24Fc treatment decreased weight loss, wasting syndrome, intractable diarrhea, and AIDS morbidity and mortality, while it was well tolerated by SIV-infected animals. Corresponding to the elimination of intractable diarrhea, CD24Fc significantly reduced the expression of IL-6 and indoleamine 2, 3-dioxygenase-1 in peripheral blood mononuclear cell and inflammation in the ileum, colon and rectum based on the reduction of inflammatory cells, pathological scores and expression of inflammatory cytokines. Furthermore, although CD24Fc did not restore CD4+ T cell number or significantly change T cell subsets or CD4+ T cell activation, it maintained low levels of plasma soluble CD14, CD8+ T cell activation, viral load and proviral load in the peripheral blood mononuclear cells and marrow. These results suggested that CD24Fc confers protection to SIV-infected ChRMs against progression to AIDS. It was also implied that CD24Fc may be a potential therapeutic approach for the control of HIV-1/AIDS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Antiviral Research - Volume 157, September 2018, Pages 9-17
Journal: Antiviral Research - Volume 157, September 2018, Pages 9-17
نویسندگان
Ren-Rong Tian, Ming-Xu Zhang, Lin-Tao Zhang, Peng Zhang, Jian-Ping Ma, Mingyue Liu, Martin Devenport, Pan Zheng, Xiao-Liang Zhang, Xiao-Dong Lian, Mei Ye, Hong-Yi Zheng, Wei Pang, Gao-Hong Zhang, Li-Guo Zhang, Yang Liu, Yong-Tang Zheng,