کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8525241 | 1557941 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of growth factors in diabetes mellitus and its complications: A general review
ترجمه فارسی عنوان
نقش عوامل رشد در دیابت و عوارض آن: بررسی کلی
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کلمات کلیدی
insulin-like growth factor–1EGFDFUPARPET-1DCMIGF-1ACRNADPHEPOCTGFNF-kBFGFMAPK - MAPKalbumin/creatinine ratio - آلبومین / کراتینین نسبتAldose reductase - آلدووز ردوکتازerythropoietin - اریتروپویتینnicotinic acid adenine dinucleotide phosphate - اسید نیکوتین اسید آدنین دینکلوتید فسفاتendothelin-1 - اندوتلین-1Oxidative stress - تنش اکسیداتیوDiabetes mellitus - دیابت قندیdiacylglycerol - دیسیل گلیسیرینdiabetic retinopathy - رتینوپاتی دیابتیDAG - روزAge - سنepidermal growth factor - عامل رشد اپیدرمیConnective tissue growth factor - فاکتور رشد بافت همبندfibroblast growth factor - فاکتور رشد فیبروبلاستnuclear factor kappaB - فاکتور هسته ای kappaBAdvanced glycation end-product - محصول نهایی پیشرفته glycationDiabetic nephropathy - نفروپاتی دیابتیdiabetic neuropathy - نوروپاتی دیابتیNitric oxide - نیتریک اکسیدmitogen-activated protein kinase - پروتئین کیناز فعال با mitogendiabetic cardiomyopathy - کاردیومیوپاتی دیابتی یا بیماری قلبی دیابتی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
چکیده انگلیسی
Diabetes mellitus (DM) is a major endocrine metabolic disease and is marked by a lack of insulin. The complication of DM is one of the most difficult problems in medicine. The initial translational studies revealed that growth factors have a major role in integrating tissue physiology and in embryology as well as in growth, maturation and tissue repair. In some tissues affected by diabetes, growth factors are induced by a relative deficit or excess. Fibroblast growth factor 21 (FGF21) is a promising regulator of glucose and lipid metabolism with multiple beneficial effects including hypoglycemic and lipid-lowering. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these complications in diabetes. Increase or decrease in the production of transforming growth factor-β1 (TGF-β1) has been associated with diabetic nephropathy and retinopathy. The insulin-like growth factor-I (IGF-I) is a naturally-occurring single chain polypeptide which has been widely used in the treatment of diabetic glomerular and renal tubular injuries. This review summarizes the recent evidences for an involvement of growth factors in diabetic complications, focusing on their emergence in sequence of events leading to vascular complications or their potential therapeutic role in these diseases. Growth factor therapy in diabetic foot ulcers is already a clinical reality. As methods to finely regulate growth factors in a tissue and time-specific manner are further developed and tested, regulation of the growth factor to normal level in vivo may well become a therapy to prevent and treat diabetic complications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 101, May 2018, Pages 510-527
Journal: Biomedicine & Pharmacotherapy - Volume 101, May 2018, Pages 510-527
نویسندگان
Guang-Jiang Shi, Guang-Rui Shi, Jia-yin Zhou, Wen-jin Zhang, Chen-ying Gao, Ya-ping Jiang, Zhen-Guo Zi, Hai-hong Zhao, Yong Yang, Jian-Qiang Yu,