کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8534915 | 1560525 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neurobehavioral and biochemical modulation following administration of MgO and ZnO nanoparticles in the presence and absence of acute stress
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
In this work, the effects of MgO and ZnO nanoparticles were investigated on some behavioral, hormonal and biochemical changes following acute stress. Wistar male rats were divided into groups of control, different times of restraint stress (90, 180 and 360â¯min), nano-MgO or nano-ZnO alone and with acute restraint stress. Anxiety-like behaviors and pain perception were evaluated by elevated plus maze and hot plate apparatus respectively. Levels of corticosterone hormone, malondialdehyde (MDA) and catalase activity, Mg, Zn, Fe and Ca were evaluated in the serum and hippocampus. The results showed that nano-MgO and nano-ZnO improved anxiety induced by restraint stress and reduced locomotor activity significantly at high doses, while at low doses could induce analgesia in the non-restraint group. Corticosterone level increased temporarily in the presence of 360â¯min stress while it was reduced in the stress of 90â¯min just 2â¯h after stress induction. The highest dose of nano-MgO increased the corticosterone level in non-restraint animals while nano-ZnO reduced it in all the groups. The 90â¯min stress was increased MDA level and nanoparticles decreased catalase activity in the hippocampus significantly. Influences of both nanoparticles on levels of Mg, Zn, Fe and Ca in the serum and hippocampus seem to be more visible than the other measured biochemical factors. Accordingly, in acute stress conditions, low doses of nano-MgO and nano-ZnO had suitable effects on behavioral responses. It seems that these effects were mostly through the central and peripheral changes of mentioned element's content and acute stress could increase nanoparticles toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 203, 15 June 2018, Pages 72-82
Journal: Life Sciences - Volume 203, 15 June 2018, Pages 72-82
نویسندگان
Mozhgan Torabi, Mahnaz Kesmati, Nahid Pourreza, Hossein Najafzadeh Varzi, Hamid Galehdari,