کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537131 | 1561006 | 2019 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Speech structure links the neural and socio-behavioural correlates of psychotic disorders
ترجمه فارسی عنوان
ساختار گفتاری ارتباطات عصبی و اجتماعی و رفتاری اختلالات روان پریشی را پیوند می دهد
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کلمات کلیدی
بی نظمی، اختلال دو قطبی، جنون جوانی، اختلال فکر سرقت مرکزی، نظریه گراف،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Background: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization. Methods: Using structural and functional imaging, we investigated the neural basis and the functional relevance of the structural connectedness of speech samples obtained from 56 patients with psychosis (22 with bipolar disorder, 34 with schizophrenia). Speech structure was assessed by non-semantic graph analysis. Results: We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing speed deficits) and iv) functional outcome in patients. Of various clinical metrics, only speech connectedness was correlated with biological markers. Speech connectedness filled the dynamic range of responses better than psychometric measurements of thought disorder. Conclusions: The results provide novel evidence that speech dysconnectivity could emerge from neurodevelopmental deficits and associated dysconnectivity in psychosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 112-120
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 88, 10 January 2019, Pages 112-120
نویسندگان
Lena Palaniyappan, Natália Bezerra Mota, Shamuz Oowise, Vijender Balain, Mauro Copelli, Sidarta Ribeiro, Peter F. Liddle,