کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537485 | 1561013 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The interaction of NOS1AP, DISC1, DAOA, and GSK3B confers susceptibility of early-onset schizophrenia in Chinese Han population
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کلمات کلیدی
N-methyl-DaspartateTdTNOS1APeQTLmRNADAOADSM-IVNMDARDISC1NMDAqRT-PCRMAFPPIGSK3BGMDRFDRSCZ - SBStransmission disequilibrium test - آزمون عدم توازن انتقالEDTA - اتیلن دی آمین تترا استیک اسید ethylene diamine tetraacetic acid - اتیلن دیامین تتراستیک اسیدEarly-onset schizophrenia - اسکیزوفرنی زودهنگامSchizophrenia - اسکیزوفرنی یا شیزوفرنیDiagnostic and Statistical Manual of Mental Disorders-Fourth Edition - راهنمای تشخیصی و آماری اختلالات روانی - نسخه چهارمSerum level - سطح سرمیEOs - عناوینpre-pulse inhibition - مهار پیش از پالسfalse discovery rate - میزان کشف کاذبMINI - مینیMini International Neuropsychiatric Interview - مینی اینترنشنال بین المللی عصبیquantitative reverse-transcription polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی معکوس رونویسیSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیGeneralized Multifactor Dimensionality Reduction - کاهش ضریب مولتی فاکتور کلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
Although many major breakthrough had identificated potential susceptibility genes for schizophrenia, the aetiology of schizophrenia is still unknown. In the present study, we focused on the N-methyl-Daspartate receptors related genes nitric oxide synthase 1 adaptor gene (NOS1AP), disrupted in schizophrenia 1 gene (DISC1), d-amino acid oxidase activator gene (DAOA), and glycogen synthase kinase 3-beta gene (GSK3B). A family-based genetic association study (459 Han Chinese subjects in 153 nuclear families) using 3 single nucleotide polymorphisms in NOS1AP, 2 in DISC1, 1 in DAOA and 1 in GSK3B was conducted. We found rs12742393 have just positive trend with schizophrenia (SCZ) (p = 0.07) after FDR correction. NOS1AP mRNA and serum levels were significantly elevated in SCZ patients (p < 0.001; p < 0.001) compared with healthy control. However, expression Quantitative Trait Loci (eQTL) analysis have demonstrated that rs12742393 genotype were not significantly associated with the NOS1AP mRNA expression. GMDR identified a significant seven-locus interaction model involving (NOS1AP-rs348624, rs12742393, rs1415263, DISC1-rs821633, rs1000731, DAOA-rs2391191and GSK3B- rs6438552) with a good testing accuracy (0.72). Our finding suggested statistically significant role of interaction of NOS1AP, DISC1, DAOA, and GSK3B polymorphisms (NOS1AP-rs348624, rs12742393, rs1415263, DISC1-rs821633, rs1000731, DAOA-rs2391191and GSK3B-rs6438552) in EOS susceptibility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 81, 2 February 2018, Pages 187-193
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 81, 2 February 2018, Pages 187-193
نویسندگان
Guoqin Hu, Chengqing Yang, Lei Zhao, Yong Fan, Qinyu Lv, Jing Zhao, Minghuan Zhu, Xiangqing Guo, Chenxi Bao, Ahong Xu, Yong Jie, Yaqing Jiang, Chen Zhang, Shunying Yu, Zuowei Wang, Zezhi Li, Zhenghui Yi,