کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8542505 | 1561451 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis
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کلمات کلیدی
SAHShine-DalgarnoAdoCblRNAPS-adenosylhomocysteineORFsSAMriboswitchesRBSCSPsFMNTPPRNA polymerase - آرانای پلیمراز، RNA پلیمراز Aptamer - آپتامرهاS-adenosylmethionine - اس-ادنوزیل متیونینGene expression - بیان ژنThiamine pyrophosphate - تیامین پری فسفاتTranscription termination - خاتمه انتقالRibosomal binding site - سایت پیوند ریبوزومیOpen reading frames - فریم های خواندن را باز کنیدflavin mononucleotide - فلاون مونونوکلئوتیدVirulence - ویروسی شدنBacterial pathogenicity - پاتوژنز باکتریاییcold shock proteins - پروتئین های شوک سرد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status. Sudden deprivation of nutrients or key metabolites, changes in surrounding pH, and temperature shifts are the most important examples of such parameters. To elicit a proper response to such fluctuations, bacterial cells coordinate the expression of parameter-relevant genes. Although protein-mediated control of gene expression is well appreciated since many decades, RNA-based regulation has been discovered in early 2000s as a parallel level of regulation. Small regulatory RNAs have emerged as one of the most widespread and important gene regulatory systems in bacteria with rare representatives found in Archaea and Eukarya. Riboswitches and thermosensors are cis-encoded RNA regulatory elements that employ different mechanisms to regulate the expression of related genes controlling key metabolic pathways and genes of temperature relevant proteins including virulence factors. The extent of RNA contributions to gene regulation is not completely known even in well-studied models such E. coli and B. subtilis. In depth understanding of riboswitches is promising for opportunity to discover a narrow spectrum antibacterial drugs that target riboswitches of essential metabolic pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Non-coding RNA Research - Volume 3, Issue 2, June 2018, Pages 54-63
Journal: Non-coding RNA Research - Volume 3, Issue 2, June 2018, Pages 54-63
نویسندگان
Jameel M. Abduljalil,