کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8544692 | 1561551 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrochemical remediation of amoxicillin: detoxification and reduction of antimicrobial activity
ترجمه فارسی عنوان
اصلاح الکتروشیمیایی آموکسی سیلین: سم زدایی و کاهش فعالیت ضد میکروبی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Amoxicillin (AMX) is one of the most commonly prescribed antibiotics around the world to treat and prevent several diseases in both human and veterinary medicine. Incomplete removal of AMX during wastewater treatment contributes to its presence in water bodies and drinking water. AMX is an emerging contaminant since its impact on the environment and human health remains uncertain. This contribution was aimed to evaluate the electrochemical oxidation (EO) of AMX using different anodes in tap water, NaCl or Na2SO4 solutions and to evaluate the potential toxicity of remaining AMX and its by-products on zebrafish early-life stages. Chemical intermediates generated after EO were determined by mass spectrometry and their resulting antimicrobial activity was evaluated. AMX did not induce significant mortality in zebrafish during extended exposure but affected zebrafish development (increased body length) from 6.25â¯mg/L to 25â¯mg/L and inhibited enzymatic biomarkers. Carbon modified with titanium oxide (TiO2@C) anode achieved complete AMX removal in just a few minutes and efficiency of the supported electrolytes occurred in the following order: 0.1â¯M NaClâ¯>â¯0.1â¯M Na2SO4â¯>â¯0.01â¯M NaClâ¯>â¯tap water. The order of potential toxicity to zebrafish early life-stages related to lethal and sublethal effects was as follows: 0.1â¯M Na2SO4 > 0.1â¯M NaCl >0.01â¯M NaClâ¯=â¯tap water. Additionally, the EO of AMX using TiO2@C electrode with 0.01â¯M NaCl was able to inhibit the antimicrobial activity of AMX, reducing the possibility of developing bacterial resistance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 291, 1 August 2018, Pages 162-170
Journal: Chemico-Biological Interactions - Volume 291, 1 August 2018, Pages 162-170
نویسندگان
Lara Barroso Brito, Luane Ferreira Garcia, Marcos Pereira Caetano, Germán Sanz Lobón, Mayk Teles de Oliveira, Rhaul de Oliveira, Ieda Maria Sapateiro Torres, Alfonso Yepez, Boniek Gontijo Vaz, Rafael Luque, Cesar Koppe Grisolia,