کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8544837 1561556 2018 37 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, spectroscopic, physicochemical and structural characterization of tetrandrine-based macrocycles functionalized with acridine and anthracene groups: DNA binding and anti-proliferative activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Synthesis, spectroscopic, physicochemical and structural characterization of tetrandrine-based macrocycles functionalized with acridine and anthracene groups: DNA binding and anti-proliferative activity
چکیده انگلیسی
In this work we report on the synthesis and characterization of two new tetrandrine-based receptors and their binding properties towards a series of nucleotides and ds-DNA, in aqueous at pH = 7.2, by UV-Vis and fluorescence spectroscopy. Both receptors exhibit high affinity (K ∼ 105 M−1) and sequence selectivity for ds-DNA, in an intercalation binding mode. These studies were accompanied with single-crystal X-ray diffraction analysis and molecular modelling. Additionally, the anti-proliferative studies of the derivatives on different cancer cell lines reveal promising activities of the compounds.221
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 286, 25 April 2018, Pages 34-44
نویسندگان
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