کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8544837 | 1561556 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, spectroscopic, physicochemical and structural characterization of tetrandrine-based macrocycles functionalized with acridine and anthracene groups: DNA binding and anti-proliferative activity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
In this work we report on the synthesis and characterization of two new tetrandrine-based receptors and their binding properties towards a series of nucleotides and ds-DNA, in aqueous at pHâ¯=â¯7.2, by UV-Vis and fluorescence spectroscopy. Both receptors exhibit high affinity (Kâ¯â¼â¯105â¯Mâ1) and sequence selectivity for ds-DNA, in an intercalation binding mode. These studies were accompanied with single-crystal X-ray diffraction analysis and molecular modelling. Additionally, the anti-proliferative studies of the derivatives on different cancer cell lines reveal promising activities of the compounds.221
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 286, 25 April 2018, Pages 34-44
Journal: Chemico-Biological Interactions - Volume 286, 25 April 2018, Pages 34-44
نویسندگان
Viviana Calvillo-Páez, Rogerio R. Sotelo-Mundo, Mario Leyva-Peralta, Juan Carlos Gálvez-Ruiz, David Corona-MartÃnez, Ramón Moreno-Corral, Raymundo Escobar-Picos, Herbert Höpfl, Octavio Juárez-Sánchez, Karen Ochoa Lara,