کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8550949 1562105 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benchmark dose analysis of multiple thyroid toxicity endpoints in ovariectomized rats exposed to propylthiouracil
ترجمه فارسی عنوان
تجزیه و تحلیل دوز بالغ چندین نقطه انتهایی سمیت تیروئید در موشهای تخمدانهای اپیلتیوآوراسیس
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Benchmark dose (BMD) analysis is generally recognized superior to generate a point of departure (PoD) to conduct risk assessment on environmental toxicants, comparing with the traditionally employed no observed adverse effect level (NOAEL) or lowest observed adverse effect level (LOAEL) methods. However, only a few studies compared the two on producing PoD of thyroid toxicity caused by environmental chemicals. Here, we presented BMD analyses on several thyroid toxicity endpoints caused by a model chemical - propylthiouracil (PTU). Adult female rats underwent ovariectomy were randomly assigned into groups receiving different doses of PTU (0, 0.1, 0.5, 1.0, and 5.0 mg/kg bw) through gavage for 8 days. Results show that PTU induces significant dose-dependent changes of serum total thyroxine (tT4), total triiodothyronine (tT3), thyroid stimulating hormones, liver type I 5′-deiodinonase (5′-DI) and malic enzyme (ME) activity with profound histopathological exacerbation. BMD and BMDL results (0.03 and 0.01 mg/kg bw respectively) from Hill model of liver 5′-DI activity were accepted based on selection criteria in the benchmark dose analysis. In summary, BMD analysis results in much lower PoD (0.01 mg/kg bw) than LOAEL (0.1 mg/kg bw) in PTU induced thyroid toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 97, August 2018, Pages 120-126
نویسندگان
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