کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551104 | 1562107 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology
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کلمات کلیدی
OECDALTRBCMCVChlNCESHCTWBCTDIGLPMCHCMCHMNPCEsPLTCinnamomum cassia - Cianamomum cassiamicronucleated polychromatic erythrocytes - erythrocytes پلی کروماتیک میکرونAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییnormochromatic erythrocytes - اریتروسیتهای نورموشروماتیکaspartate transaminase - ترانس آمیناز آسپارتاتtriglyceride - تریگلیسریدGood Laboratory Practice - تمرین خوب آزمایشگاهیMean corpuscular volume - حجم متوسط مایعBUN - خوبCinnamon - دارچینChinese hamster lung - ریه هامستر چینیSubchronic - زیرشاخه ایOrganization for Economic Co-operation and Development - سازمان همکاری و توسعه اقتصادیToxicity - سمی بودنGenotoxicity - سمیت ژنتیکیmean corpuscular hemoglobin - متوسط هموگلوبین عضلانیMean corpuscular hemoglobin concentration - میانگین غلظت هموگلوبین عروق کرونرblood urea nitrogen - نیتروژن اوره خونhematocrit - هماتوکریتHemoglobin - هموگلوبینHgb - هورمون رشدPlatelet - پلاکتhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراtotal bilirubin - کل بیلی روبینtotal protein - کل پروتئینtotal cholesterol - کلسترول تامwhite blood cell - گلبول سفید خونred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology In vitro and in vivo safety studies of cinnamon extract (Cinnamomum cassia) on general and genetic toxicology](/preview/png/8551104.png)
چکیده انگلیسی
Cinnamomum cassia has been widely used as a natural product to treat diseases in Asia due to its diverse pharmacological functions including anti-inflammatory, anti-oxidant, anti-microbial, anti-diabetic, and anti-tumor effects. Despite its ethnomedicinal benefits, little information regarding its toxicity is currently available. The aim of this study was to evaluate its potential long-term toxicity and genotoxicity in compliance with test guidelines of the Organization for Economic Cooperation and Development. A 13-week repeat-dose oral toxicity study revealed that body weights of rats were normal after receiving cinnamon extract at up to 2000â¯mg/kg. High-dose intake of cinnamon extract (2000â¯mg/kg) showed potential nephrotoxicity and hepatotoxicity to both males and females as evidenced by obvious increases of kidney/liver weight along with a small but statistically elevation of total cholesterol level. Overall findings from genetic toxicity testing battery including Ames test, in vitro mammalian cell micronucleus assay, and in vivo bone marrow micronucleus assay indicated that cinnamon extract was not mutagenic or clastogenic. In conclusion, cinnamon extract may possess potential nephrotoxicity and hepatotoxicity at dose higher than its recommended daily safe dose. Further study is needed to clarify the mechanism involved in its induction of liver and kidney injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 115-123
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 115-123
نویسندگان
Jun-Won Yun, Ji-Ran You, Yun-Soon Kim, Seung-Hyun Kim, Eun-Young Cho, Jung-Hee Yoon, Euna Kwon, Ja-June Jang, Jin-Sung Park, Hyoung-Chin Kim, Jeong-Hwan Che, Byeong-Cheol Kang,