کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551324 | 1562107 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion
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کلمات کلیدی
TSNAsNNKNBWP&TENDSNNNN-nitrosonornicotine2-NAe-liquidCRMCFPHCIFDASPEHPHCCambridge filter padVOCNCILOQPAH4-ABPGC-MS - کروماتوگرافی گازی-طیف سنج جرمی4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone - 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone4-aminobiphenyl - 4-آمینوبیفنیلB[a]P - B [a] PEthylene glycol - اتیلن گلیکولCombustion - احتراقU.S. Food and Drug Administration - اداره غذا و داروی ایالات متحدهSolid phase extraction - استخراج فاز جامدISO - ایزوBenzo[a]pyrene - بنزو [a] پییرنHealth Canada Intense - بهداشت کانادا شدیدVolatile organic compound - ترکیب آلی فرارPurge and trap - تمیز کردن و تلهTobacco specific nitrosamines - تنباکو ویژه نیتروستامینیseconds - ثانیهLOD یا Limit of detection - حد تشخیصdiethylene glycol - دیتیلن گلیکولdays - روزهاInternational Organization for Standardization - سازمان بین المللی استاندارد سازیhours - ساعت هاElectronic nicotine delivery system - سیستم تحویل نیکوتین الکترونیکیE-cigarette - سیگار الکترونیکیFederal Food, Drug, and Cosmetic Act - قانون غذا، دارو و لوازم آرایشی فدرالlimit of quantification - محدودیت اندازه گیریlimit of detection - محدودیت تشخیصCooperation Centre for Scientific Research Relative to Tobacco - مرکز همکاری تحقیقات علمی مربوط به دخانیاتICH - منharmful and potentially harmful constituents - مواد مضر و بالقوه مضرHarmful and potentially harmful constituent - مواد مضر و مضرPolyaromatic hydrocarbon - هیدروکربن PolyaromaticPropylene glycol - پروپیلن گلیکولgas chromatography with mass spectrometry - کروماتوگرافی گاز با طیف سنج جرمیInternational Conference on Harmonisation - کنفرانس بین المللی هماهنگیCORESTA - کورستاelectron ionization - یونیزاسیون الکترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion](/preview/png/8551324.png)
چکیده انگلیسی
U.S. FDA draft guidance recommends reporting quantities of designated harmful and potentially harmful constituents (HPHCs) in e-cigarette e-liquids and aerosols. The HPHC list comprises potential matrix-related compounds, flavors, nicotine, tobacco-related impurities, leachables, thermal degradation products, and combustion-related compounds. E-cigarettes contain trace levels of many of these constituents due to tobacco-derived nicotine and thermal degradation. However, combustion-related HPHCs are not likely to be found due to the relatively low operating temperatures of most e-cigarettes. The purpose of this work was to use highly sensitive, selective, and validated analytical methods to determine if these combustion-related HPHCs (three aromatic amines, five volatile organic compounds, and the polycyclic aromatic hydrocarbon benzo[a]pyrene) are detectable in commercial refill e-liquids, reference e-cigarette e-liquids, and aerosols generated from rechargeable e-cigarettes with disposable cartridges (often referred to as “cig-a-likes”). In addition, the transfer efficiency of these constituents from e-liquid to aerosol was evaluated when these HPHCs were added to the e-liquids prior to aerosol formation. This work demonstrates that combustion-related HPHCs are not present at measurable levels in the commercial and reference e-liquids or e-cigarette aerosols tested. Additionally, when combustion-related HPHCs are added to the e-liquids, they transfer to the aerosol with transfer efficiencies ranging from 49% to 99%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 153-160
Journal: Regulatory Toxicology and Pharmacology - Volume 95, June 2018, Pages 153-160
نویسندگان
Karl A. Wagner, Jason W. Flora, Matt S. Melvin, Karen C. Avery, Regina M. Ballentine, Anthony P. Brown, Willie J. McKinney,