کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551997 | 1562139 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxyurea embryotoxicity is enhanced in P53-deficient mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
p53CRLTrp53DNA - DNA یا اسید دزوکسی ریبونوکلئیکSAL - WILLdeoxyribonucleic acid - اسید deoxyribonucleicOrganogenesis - اندام زایی، ارگانوژنزBirth defects - بیماری مادرزادی، اختلال مادرزادیteratogen - تراتوژنgestational day - روز بارداریSaline - سالینDevelopmental toxicity - سمیت توسعهHydroxyurea - هیدروکسی اوره
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hydroxyurea, a ribonucleotide reductase inhibitor, is a potent teratogen in mice, causing severe limb and skeletal defects. The exposure of gestation day nine murine embryos to hydroxyurea elicits an early embryonic stress response that involves activation of the P53 transcription factor. The impact of this P53 activation on the embryotoxicity of hydroxyurea- is not known. The goal of this study was to test the hypothesis that P53 acts to suppress hydroxyurea embryotoxicity. Trp53+/â timed pregnant mice were treated with saline or hydroxyurea (200 or 400â¯mg/kg) on gestation day nine; fetuses were examined for viability and external and skeletal malformations on gestation day eighteen. Neither the deletion of Trp53 nor hydroxyurea treatment significantly affected fetal growth although a trend towards a decrease in fetal weights was observed in Trp53-/- fetuses. However, hydroxyurea induced a significantly higher incidence of malformations and resorptions in Trp53-/- fetuses compared to their wildtype littermates. Thus, fetal P53 genotype is an important determinant of the effects of hydroxyurea on organogenesis-stage embryos.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 81, October 2018, Pages 28-33
Journal: Reproductive Toxicology - Volume 81, October 2018, Pages 28-33
نویسندگان
Nazem El Husseini, Barbara F. Hales,