کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8552626 | 1562146 | 2017 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Persistent testicular structural and functional alterations after exposure of adult rats to atrazine
ترجمه فارسی عنوان
تغییرات ساختاری و عملکردی مداوم بیضه پس از قرار گرفتن در معرض موش های بالغ به آترازین
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Atrazine is an endocrine disruptor affecting testicular steroidogenesis, and promoting testicular atrophy and 3β-HSD reduction. However, it remains unknown whether these effects are reversible or permanent. To address this issue was the aim of this study. Exposition of rats to 200 mg/kg of atrazine resulted in transient increase in testicular weight, seminiferous tubules dilation and atrophy, and reduction in Leydig cell 3β-HSD. Testicular atrophy and 3β-HSD reduction were more pronounced after the recovery period of 75 days. There was increase in aromatase expression after long-term exposure but it returned to control level after recovery. Moreover, there was increase in ED1â/ED2+, ED1+/ED2+ and ED1+/ED2â macrophages, in the recovery group. These macrophages were positive for 3β-HSD, thereby raising possibility of their involvement in steroidogenesis. These findings further emphasize the adverse effects of atrazine on male reproduction, highlighting that testicular damages may be irreversible even after a recovery period longer than the spermatogenic cycle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 73, October 2017, Pages 201-213
Journal: Reproductive Toxicology - Volume 73, October 2017, Pages 201-213
نویسندگان
Elisângela Martins-Santos, Cristiano Guimarães Pimenta, Pollyana Rabelo Nunes Campos, Mariana Brandão Franco, Dawidson Assis Gomes, Germán Arturo Bohórquez Mahecha, Cleida Aparecida Oliveira,