کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8552626 1562146 2017 44 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Persistent testicular structural and functional alterations after exposure of adult rats to atrazine
ترجمه فارسی عنوان
تغییرات ساختاری و عملکردی مداوم بیضه پس از قرار گرفتن در معرض موش های بالغ به آترازین
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Atrazine is an endocrine disruptor affecting testicular steroidogenesis, and promoting testicular atrophy and 3β-HSD reduction. However, it remains unknown whether these effects are reversible or permanent. To address this issue was the aim of this study. Exposition of rats to 200 mg/kg of atrazine resulted in transient increase in testicular weight, seminiferous tubules dilation and atrophy, and reduction in Leydig cell 3β-HSD. Testicular atrophy and 3β-HSD reduction were more pronounced after the recovery period of 75 days. There was increase in aromatase expression after long-term exposure but it returned to control level after recovery. Moreover, there was increase in ED1−/ED2+, ED1+/ED2+ and ED1+/ED2− macrophages, in the recovery group. These macrophages were positive for 3β-HSD, thereby raising possibility of their involvement in steroidogenesis. These findings further emphasize the adverse effects of atrazine on male reproduction, highlighting that testicular damages may be irreversible even after a recovery period longer than the spermatogenic cycle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 73, October 2017, Pages 201-213
نویسندگان
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