کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553371 | 1562584 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The promotion on cell growth of androgen-dependent prostate cancer by antimony via mimicking androgen activity
ترجمه فارسی عنوان
ترویج رشد سلول سرطانی پروستات وابسته به آندروژن توسط آنتیموان توسط اثر تقلبی آندروژن
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کلمات کلیدی
BicalutamideDHTIGFABSCASqRT-PCRpTHAREsantibodies - آنتی بادی هاantimony - آنتیموان IARC یا International Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانInternational Agency for Research on Cancer - آژانس بین المللی تحقیقات سرطانtestosterone - تستوسترونDihydrotestosterone - دی هیدروتستوسترونCell growth - رشد یاختهInsulin-like growth factor - فاکتور رشد مانند انسولینBenign prostatic hyperplasia - هیپرپلازی خوش خیم پروستاتBPH - هیپرپلازی خوش خیم پروستات یا BPHquantitative real-time polymerase chain reaction - واکنش زنجیره ای پلیمراز کمی زمان واقعی استpat - پاتAndrogen Receptor - گیرنده آندروژنی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Antimony is a widely used heavier pnictogens in industry, and its toxicity has been a matter of concern. Although previous studies have suggested that antimony may have the function as either a tumor suppressor or an oncogene in several cancers, the molecular basis underlying antimony-mediated transformation is still unclear. In the current study, we attempt to elucidate the potential role of antimony in the development of prostate cancer. Our results showed that the concentration of antimony was much higher in serum of prostate cancer patients, and was closely associated with poor outcome of patients who underwent radical prostatectomy. Additionally, low dose of antimony could promote proliferation and invasion of androgen-dependent prostate cancer cell line LNCaP cells in vitro and in vivo. The mechanistic studies demonstrated that exposure to antimony triggered the phosphorylation of androgen receptor (AR), which transcriptionally regulates the expression of androgen-related targets, including PSA and NKX3.1. Overall, our results unearthed that antimony could promote tumor growth by mimicking androgen activity in androgen-dependent prostate cancer cells. Therefore, these findings expanded our understanding on the molecular mechanism of antimony in tumorigenesis and tumor progression of prostate cancer, and it appears to be an inspiring strategy to restrain prostate cancer by inhibiting antimony-induced androgen-like effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 136-142
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 136-142
نویسندگان
Changwen Zhang, Penghao Li, Yingwu Wen, Guowei Feng, Yu Liu, Yangyi Zhang, Yong Xu, Zhihong Zhang,