کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553791 | 1562694 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of heptanol and ethanol on excitation wave propagation in a neonatal rat ventricular myocyte monolayer
ترجمه فارسی عنوان
اثر هپتانول و اتانول بر روی انتشار موج در یک سلول میوکسی بطنی مغز نوزاد
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کلمات کلیدی
هپتانول، اتانول، موج تحریک قلب، نقشه برداری نوری، آریتمی، جدا کردن،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
In this work, the action of heptanol and ethanol was investigated in a two-dimensional (2D) model of cardiac tissue: the neonatal rat ventricular myocyte monolayer. Heptanol is known in electrophysiology as a gap junction uncoupler but may also inhibit voltage-gated ionic channels. Ethanol is often associated with the occurrence of arrhythmias. These substances influence sodium, calcium, and potassium channels, but the complete mechanism of action of heptanol and ethanol remains unknown. The optical mapping method was used to measure conduction velocities (CVs) in concentrations of 0.05-1.8â¯mM heptanol and 17-1342â¯mM ethanol. Heptanol was shown to slow the excitation wave significantly, and a mechanism that involves a simultaneous action on cell coupling and activation threshold was suggested. Whole-cell patch-clamp experiments showed inhibition of sodium and calcium currents at a concentration of 0.5â¯mM heptanol. Computer modeling was used to estimate the relative contribution of the cell uncoupling and activation threshold increase caused by heptanol. Unlike heptanol, ethanol slightly influenced the CV at clinically relevant concentrations. Additionally, the critical concentrations for re-entry formation in ethanol were determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 51, September 2018, Pages 136-144
Journal: Toxicology in Vitro - Volume 51, September 2018, Pages 136-144
نویسندگان
A.D. Podgurskaya, V.A. Tsvelaya, S.R. Frolova, I.Y. Kalita, N.N. Kudryashova, K.I. Agladze,