کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634181 | 1569092 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Arginine pretreatment enhances circulating endothelial progenitor cell population and attenuates inflammatory response in high-fat diet-induced obese mice with limb ischemia
ترجمه فارسی عنوان
پیشگیری از آرژنین باعث افزایش جمعیت سلول های پیش داوری آندوتلیال و کاهش پاسخ واکنش التهابی به موش های چاق مبتلا به رژیم های با چربی با ایسکمی اندام
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کلمات کلیدی
EPCsMCP-1ICAM-1SDF-1MMP-9ECs - EC هاArginine - آرژنین Arg - ارگinflammation - التهاب( توروم) Limb ischemia - ایسکمی اندامinterleukin - اینترلوکینtumor necrosis factor-α - تومور نکروز عامل αEndothelial progenitor cells - سلول های پیش ساز اندوتلیالEndothelial cells - سلولهای اندوتلیالstromal cell-derived factor-1 - فاکتور 1 حاصل از استروما سلولVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)TNF-α - فاکتور نکروز توموری آلفاmatrix metallopeptidase-9 - ماتریکس متالوپپتیداز -9Obesity - مرض چاقیNitric oxide - نیتریک اکسیدmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Obesity is a global health problem with an up-regulated inflammatory reaction. Obesity-induced endothelial progenitor cells (EPCs) dysfunction is associated with vascular complications that may contribute to critical limb ischemia. Arginine (Arg) is an amino acid with immune-modulatory property and has been found to promote EPCs mobilization in disease conditions. Thus in the present investigation, we hypothesized that arginine given to a murine model of diet-induced obesity would increase circulating EPCs and mitigate the inflammatory reactions in response to limb ischemia. Mice were divided into normal group (NC), high-fat group (HC), and high-fat Arg group (HA). Mice in the HC group were fed with a diet containing 60% energy as fat for 8 weeks, while HA group were initially fed with the same high-fat diet for 4 weeks and later shifted to a high-fat diet enriched with 2% Arg for the remaining 4 weeks. Then mice in the HC and HA groups underwent ischemic operations and were euthanized at either day 1 or day 7 after limb ischemia. The results showed that, compared to the ischemic HC group, the ischemic HA group had higher circulating EPCs at day 1 post-ischemia and higher muscle stromal cell-derived factor-1 and interleukin (IL)-10 mRNA expressions at day 7 after ischemia. In contrast, plasma leptin concentration and expressions of IL-1β and tumor necrosis factor-α mRNAs by adipocytes were down-regulated. These findings suggest that obese mice treated with Arg-containing high-fat diet enhanced circulating EPCs percentage and attenuated inflammatory reaction in response to limb ischemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 53, May 2018, Pages 67-76
Journal: Nutrition Research - Volume 53, May 2018, Pages 67-76
نویسندگان
Yu-Fan Kuo, Chiu-Li Yeh, Juey-Ming Shih, Yao-Ming Shih, Sung-Ling Yeh,