کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646233 | 1570073 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification, expression, and methylation of miR-7110 and its involvement in type 1 diabetes mellitus
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کلمات کلیدی
FBGmiRNAsIDDMDCCTT1DMHbA1cESTs - EST هاEST - استBiomarker - بیومارکرDiagnostic - تشخیصExpressed sequence tags - تگ های توالی بیان شدهDiabetes mellitus - دیابت قندیInsulin dependent diabetes mellitus - دیابت قندی وابسته به انسولینtype 1 diabetes mellitus - دیابت نوع 1microRNAs - ریز آرانایWorld Health Organization - سازمان بهداشت جهانیfasting blood glucose - قند خون ناشتاGlycosylated hemoglobin - هموگلوبین گلیکوزیله شدهWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification, expression, and methylation of miR-7110 and its involvement in type 1 diabetes mellitus Identification, expression, and methylation of miR-7110 and its involvement in type 1 diabetes mellitus](/preview/png/8646233.png)
چکیده انگلیسی
MicroRNAs are a novel group of universally present non-coding RNA that has been implicated in the wide-ranging biological process and are critical in the manifestation of diverse disease including diabetes mellitus (DM). Although there are so many numbers of micro RNAs involved in DM none of them effective for the suppression of Type I DM (T1DM), hence there is an urgent need for identifying exact microRNAs that may serve as a candidate biomarker for T1DM. Moreover, we know that expressed sequence tags (ESTs) are random single pass sequences reads which displays the condition/tissue-specific transcribes of an organism. In the present study, we have applied bioinformatics tools to identify hsa-mir-7110-5p from diabetes mellitus using EST resources. Our studies revealed that hsa-mi-7110 was confirmed in the T1DM specific EST sequence among the predicted miRNA secondary structure. It has been known that miRNAs are known to be an important factor involved in the initiation and progression of T1DM. Based on the above information, we also deciphered the molecular mechanism and the role of miR-7110 from T1DM patients and found that miR-7110 was a novel prognostic, diagnostic and therapeutic target for T1DM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Reports - Volume 11, June 2018, Pages 229-234
Journal: Gene Reports - Volume 11, June 2018, Pages 229-234
نویسندگان
Priyanka P., Mani Panagal, Pethanen Sivakumar, Vincent Gopinath, R Ananthavalli, Karthigeyan M, Sivagurunathan Paramasivam, Senthil Kumar S.R, Durairaj Sekar,